Michigan State University Osteopathic Med Specialties ICEMR
Malawi ICEMR Project Summary
The overarching goal of the ICEMR program is to establish research centers in malaria-endemic settings that will provide the necessary knowledge, tools, and evidence-based strategies for use by government organizations and health care institutions.
Malaria remains a huge problem (over 40% of the world's population are at risk of contracting the disease).
Control efforts have not been sustainable
- Drug resistant parasistes . . . and no point-of care tools to monitor them
- Insecticide resistant mosquitoes
No licensed vaccine - - and none may not be available for years to come.
Sustainable and effective malaria control requires an improved understanding of the complex interactions among the parasite, the mosquito vector, and the human host in local clinical and field settings.
Novel drugs, diagnostics, and vaccines, as well as vector management strategies will need to be developed, evaluated and ultimately utilized in malaria-endemic locations.
Thus, a multidisciplinary research approach is urgently needed to address these complex interactions at the molecular, cellular, organismic, population and field levels in malaria-endemic areas in order to provide the knowledge base necessary for improved clinical and field management of malaria, as well as to guide the development of new tools and interventions.
In The New:-
SRA "Best Poster of the year Award"
Lynn Mande (Michigan) and Esther Gondwe (Malawi) won the Society of Research Administrators International’s 2014 Symposium “Best Poster of the Year Award,” in the North America Category, for their poster: Challenges in International Travel: Covering Costs without a Credit Card.http://www.srainternational.org/about-sra-international
Brain Swelling and Death in Children with Cerebral Malaria Karl B. Seydel and others New England Journal of Medicine March 19, 2015
Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.
CONCLUSIONS: Submicroscopic malaria infectionis common and occurs early in pregnancy. SP-IPT can clear some submicroscopic infections but does not prevent new infections after administration. To effectively control pregnancy-associated malaria, new interventions are required to target women prior to their first antenatal care visit and to effectively treat and prevent all malaria infections.
Cohee LM, Kalilani-Phiri L,Boudova S, Joshi S, Mukadam R,Seydel KB, Mawindo P, Thesing P, Kamiza S, Makwakwa K, Muehlenbachs A, Taylor TE, Laufer MK. Malar J. 2014 Jul 15;13(1):274. doi: 10.1186/ 1475-2875-13-274. PMID: 25023697 [PubMed - in process]
leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.
"Malaria is an ancient disease, but it is still beating us and killing hundreds of thousands of people each year, mostly children, in sub-Saharan Africa. It is very tricky. It is the 'Voldemort' of parasites."-Terrie Taylor
For nearly three decades, Terrie Taylor, University Distinguished Professor of internal medicine in the MSU College of Osteopathic Medicine, has been researching malaria, a disease transmitted by mosquitoes that infects red blood cells and that can damage the brain. See more at: Malaria
Society of Research Administators International Excellence Award, Newcomer Level
The Excellence Award was established in 1977 in honor of the Society’s 10th anniversary. The award recognizes SRA members, organized by level of experience: newcomers, mid-career and advanced, who have excelled in meeting SRA’s purpose of expanding the knowledge and tools of research administration.
Esther Gondwe, Project Research Administrator, University of Malawi
Esther Gondwe has over 10 years experience in project management having worked and held senior positions in the Operations Department of a Development Financial Institution in Malawi. She also has over five years experience managing National Institutes of Health (NIH) subcontracts to the University of Malawi, College of Medicine from Michigan State University and University of Maryland in the United States of America. She has also managed grants from Bill and Melinda Gates Foundation and the European Development Clinical Trials Partnership (EDCTP). Esther has served as a member of a Grants Management Technical committee of the College of Medicine and has participated in the development of grant management policy and guidelines for the college. Esther is a member of the Society for Research Administrators and has attended a number of Research Administration conferences in Africa and in the United States, including Fogarty International Administrators meetings and National Council for University Research Administrators (NCURA).
- See more at: http://www.sra2013nola.org/2013-awards#sthash.hOazB9rE.dpuf