Research and Advanced Study Programs (RASP)
RASP Research Programs
The Carcinogenesis Laboratory, a unit in the College of Osteopathic Medicine, specializes in research on the origin of human cancer. Strong evidence suggests that environmental agents, including smoking, are responsible for the majority of human cancer. However, the biochemical mechanisms by which normal cells are transformed into tumor-producing cells are not yet understood. The goal is to gain insight into the processes so that strategies can be developed to interrupt or thwart this malignant transformation. Co-Directors for the Carcinogenesis Laboratory are: J. Justin McCormick, PhD, University Distinguished Professor, Dept of Biochemistry & Molecular Biology and Dept of Microbiology & Molecular Genetics, and Veronica M. Maher, PhD, University Distinguished Professor, Dept of Biochemistry & Molecular Biology and Dept of Microbiology & Molecular Genetics. During the past 33 years, Professors Maher and McCormick have secured more than $18 million in direct federal funding to support their research program on cancer. This places them above the 95th percentile of the distribution for (extramural) NIH grants over the last 25 years.
Orthopedic Biomechanics Laboratories (OBL), College of Engineering, Dept of Mechanical Engineering, Dept of Manipulative Medicine
The Orthopaedic Biomechanics Laboratories (OBL) produces cutting edge research. Roger Haut, PhD, the Director, has secured funding from the CDC in excess of $2.5 million over the past 10 years to study the mechanics of osteoarthritis. In his research on the biomechanics of skull fracture in children and infants, Haut's collaboration with MSU anthropologists has provided expertise relating to biomechanical and soft tissue injuries.
Center for Orthopedic Research
MSU Center for Orthopedic Research (MSUCOR) was established in the fall of 2007 with the arrival of Jacek Cholewicki, PhD, MSUCOM Walter F. Patenge Endowed Chair in the Dept of Osteopathic Surgical Specialties. Research projects at MSUCOR involve MSU faculty and graduate students from three MSU Colleges.
Venous Thromboembolism Research Unit
Paul Stein, MD, directs the Venous Thromboembolism Research Unit. Stein studies deep vein thrombosis and pulmonary embolisms. He directs NIH-funded multicenter studies that investigate the incidence, methods of diagnosis and therapeutic interventions for these conditions. He has published 574 papers in his professional life, and 82 in the last seven years.
International Neurologic and Psychiatric Epidemiology Program (INPEP)
Utilizes the epidemiologic methods to study neurologic and psychiatric conditions that impact public health in developing regions of the world.
Translational Neurobiology Research Unit
The Translational Neurobiology Research Unit has obtained extramural funding from the NIH, the US Army, and two NIH pre-doctoral trainee fellowships. This research group is headed by John Goudreau, DO, PhD, who is a specialist in Parkinson's Disease and other gait disorders. He has authored or co-authored numerous publications. Goudreau has mentored over 25 undergraduate, pre-doctoral, medical and post-doctoral trainees, including matriculating 2 PhD students and 2 DO-PhD students.
MSU Center for Vaccine Development and Deployment
Andrea Amalfitano, DO, PhD, Osteopathic Heritage Foundation Professor of Pediatrics, and Professor of Microbiology & Molecular Genetics was awarded a major 3-year, $480,000 grant from the MSU Foundation to help establish the MSU Center for Vaccine Development and Deployment. This Center utilizes advanced generation adenovirus-based gene transfer vectors as preventative and/or therapeutic vaccine platforms for malaria and other diseases. The Center will develop new vaccine platforms designed to elicit beneficial immune response against antigens derived from pathogens or cancer cells, so as to facilitate immune response induction to the desired antigen(s). Eventual deployment into the clinical arena is the goal of the Center.
The Institute of International Health has been extensively involved in organizing International Health Elective Clerkship opportunities, which provide an introduction for medical students to the practice of medicine in resource-poor settings.